If you drink coffee I am pretty sure you have heard of caffeine. Most people have an idea what caffeine can do to you after you drink that espresso but what is caffeine really?

Your Caffeine or 1, 3, 7-trimethylxanthine is the most widely consumed pharmacological active substance in the world. Its primary function is to stimulate the central nervous system. Chemically speaking caffeine belongs to the alkaloid family and the methylxanthine group. Caffeine is present in over 65 plant species of which the most well-known are cocoa-beans, tea and coffee. The closely related substances theophylline or 1, 3-dimethylxanthine and theobromine or 3, 7-dimethylxanthine are also found in a variety of plants.

Caffeine can occur naturally in tea, coffee, cocoa and chocolate products and is added to soft drinks and a variety of both prescription and over-the-counter drugs. Common values for the caffeine content of these foods and beverages have been set. Thus an average sized cup (150 ml) of ground roasted coffee contains around 85 mg, instant coffee 60 mg, decaffeinated coffee 3 mg, leaf or bag tea 30 mg, instant tea 20 mg and cocoa or hot chocolate 4 mg caffeine.

Absorption of caffeine from the gastrointestinal tract is rapid and virtually complete about 45 minutes after ingestion. The peak plasma caffeine concentration is reached 20-120 minutes after ingestion. Intakes of 5-8 mg caffeine/kg body weight give plasma caffeine concentrations of 8-10 mg/l. The half-life of caffeine in the plasma is 2.5-4.5 hours in young and elderly men increasing to 80 hours in newborn infants and over 100 hours in premature infants. The caffeine half-life is reduced by 28-49% in smokers, doubles in women taking oral contraceptives and rises to 15 hours in the last trimester of pregnancy. The metabolism of caffeine is species specific. In humans about 78% of caffeine is demethylated to paraxanthine and about 15% converted to theobromine and theophylline in the liver. Further demethylation and oxidation forms urates and uracil derivatives. About a dozen caffeine metabolites can be recovered in the urine but less than 3% of ingested caffeine.

Many numbers of mechanisms for the effects of caffeine have been suggested. Caffeine stimulates the release of intracellular calcium and inhibits the activity of cyclic nucleotide phosphodiesterases at concentrations between 0.5 and 1 mM. These concentrations are well above those seen in the blood in response to normal intakes of caffeine suggesting that the effects of caffeine are mediated by other mechanisms. It is now generally accepted that physiological concentrations of caffeine (about 100 μM) act by antagonising the effects of adenosine. Caffeine acts at A1 adenosine receptors which are negatively linked to adenyl cyclase and A2a adenosine receptors which are positively linked to adenyl cyclase. Hence, competition between caffeine and adenosine at cell surface A1 and A2a adenosine receptors leading to changes in the intracellular concentration of cyclic AMP is the likely mechanism underlying the physiological effects of caffeine.